Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 9/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.63 |
| ▸ | PIM1 | P11309 | 3/20 | 0.57 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.57 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.57 |
| ▸ | TTR | P02766 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | NEK4 | P51957 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12299714 | 0.88 | ESRRA (0.64) | ESRRACYP3A4PTPN1PIM1PIM2 | |
| SCHEMBL8170341 | 0.87 | ESRRA (1.00) | ESRRACYP3A4PTPN1PIM1PIM2 | |
| SCHEMBL2380967 | 0.87 | ESRRA (1.00) | ESRRACYP3A4PTPN1PIM1PIM2 | |
| SCHEMBL2384250 | 0.87 | ESRRA (1.00) | ESRRACYP3A4PTPN1PIM1PIM2 | |
| SCHEMBL12299692 | 0.85 | ESRRA (0.78) | ESRRACYP3A4PIM1PIM2CISD1 | |
| SCHEMBL13057026 | 0.84 | PTPN1 (0.59) | ESRRACYP3A4PTPN1PIM1PIM2 | |
| SCHEMBL12299735 | 0.84 | CISD1 (0.59) | ESRRACYP3A4PTPN1PIM1PIM2 | |
| SCHEMBL12299738 | 0.83 | ESRRA (0.60) | ESRRACYP3A4PTPN1PIM1PIM2 | |
| SCHEMBL12299701 | 0.81 | ESRRA (0.76) | ESRRACYP3A4PIM1PIM2CISD1 | |
| SCHEMBL13055275 | 0.80 | ESRRA (0.61) | ESRRACYP3A4PIM1PIM2CISD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237625-A1 | SUBSTITUTED PHENOXY THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-á MODULATORS | JANSSEN PHARAMCEUTICA N.V. (BE) | 2011-09-29 | — | — | US | disclosed |
| US-7846953-B2 | Substituted phenoxy thiazolidinediones as estrogen related receptor-α modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2010-12-07 | — | — | US | disclosed |
| US-20090111855-A1 | SUBSTITUTED PHENOXY THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-alpha MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237625-A1 | SUBSTITUTED PHENOXY THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-á MODULATORS | ESR2, ESRRA, ESRRB | ESRRA 2/4885CYP3A4 1190/4885PTPN1 655/4885 |
| US-20090111855-A1 | SUBSTITUTED PHENOXY THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-alpha MODULATORS | ESR2, ESRRA, ESRRG | ESRRA 2/4885CYP3A4 1174/4885PTPN1 763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.