Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.75 |
| ▸ | PIK3R1 | P27986 | 19/20 | 0.75 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.52 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12300961 | 0.93 | PIK3CA (0.71) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3C2B | |
| SCHEMBL2376500 | 0.86 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3C2B | |
| SCHEMBL2377745 | 0.85 | PIK3CA (0.77) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3C2B | |
| SCHEMBL2378018 | 0.84 | PIK3CA (0.80) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3C2B | |
| SCHEMBL2376901 | 0.83 | PIK3CA (0.79) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3C2B | |
| SCHEMBL2376490 | 0.82 | PIK3CA (0.74) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3C2B | |
| SCHEMBL13872590 | 0.81 | PIK3CA (0.70) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3C2B | |
| SCHEMBL2377106 | 0.81 | PIK3CA (0.83) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3C2B | |
| SCHEMBL2376219 | 0.80 | PIK3CA (0.75) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3C2B | |
| SCHEMBL2377905 | 0.79 | PIK3CA (0.74) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022205-B2 | Pyrimidine derivatives as PI3K inhibitor and use thereof | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-09-20 | — | — | US | disclosed |