Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 12/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2376519 | 0.81 | PIK3CA (0.73) | PIK3CAPIK3CDPIK3C2BPIK3CBMTOR | |
| SCHEMBL13872660 | 0.79 | PIK3CA (0.62) | PIK3CAPIK3R1 | |
| SCHEMBL2376228 | 0.79 | PIK3CA (0.68) | PIK3CAPIK3CDPIK3C2BPIK3CBMTOR | |
| SCHEMBL2376980 | 0.78 | PIK3CA (0.64) | PIK3CAPIK3CDPIK3C2BPIK3CBMTOR | |
| SCHEMBL2377213 | 0.78 | PIK3CA (0.71) | PIK3CAPIK3CDPIK3C2BPIK3CBMTOR | |
| SCHEMBL13872924 | 0.78 | PIK3CA (0.63) | PIK3CAPIK3R1 | |
| SCHEMBL2376686 | 0.77 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3C2BPIK3CBMTOR | |
| SCHEMBL2378090 | 0.77 | PIK3CA (0.88) | PIK3CAPIK3CDPIK3C2BPIK3CBMTOR | |
| SCHEMBL2379195 | 0.76 | PIK3CA (0.66) | PIK3CAPIK3CDPIK3C2BPIK3CBMTOR | |
| SCHEMBL2377973 | 0.76 | PIK3CA (0.66) | PIK3CAPIK3CDPIK3C2BPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022205-B2 | Pyrimidine derivatives as PI3K inhibitor and use thereof | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-09-20 | — | — | US | disclosed |