Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.52 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 3/20 | 0.31 |
| ▸ | FLT4 | P35916 | 3/20 | 0.31 |
| ▸ | KDR | P35968 | 3/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL126057 | 0.85 | BTK (0.56) | BTKTNK2FLT1FLT4KDR | |
| SCHEMBL175812 | 0.85 | BTK (0.56) | BTKTNK2 | |
| SCHEMBL12100608 | 0.83 | BTK (0.57) | BTKTNK2 | |
| SCHEMBL122066 | 0.78 | BTK (0.56) | BTKTNK2 | |
| SCHEMBL167469 | 0.78 | BTK (0.64) | BTKTNK2 | |
| SCHEMBL123836 | 0.77 | BTK (0.48) | BTKTNK2PIK3CDHTR2AHTR2C | |
| SCHEMBL16332632 | 0.77 | BTK (0.58) | BTKTNK2 | |
| SCHEMBL123306 | 0.77 | BTK (0.64) | BTKTNK2PIK3CD | |
| SCHEMBL176919 | 0.76 | BTK (0.66) | BTKTNK2PIK3CD | |
| SCHEMBL123807 | 0.73 | BTK (0.56) | BTKTNK2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424368-A1 | PYRROLOTRIAZINE COMPOUNDS | Locus Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126960-A1 | PYRROLOTRIAZINE COMPOUNDS | LOCUS PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |