Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
| ▸ | HTR1F | P30939 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12307449 | 0.85 | SMN1; SMN2 (0.35) | SMN1; SMN2GCKGRM5HTR1DHTR1B | |
| SCHEMBL12307441 | 0.84 | SMN1; SMN2 (0.38) | SMN1; SMN2GCKGRM5HTR1DHTR1B | |
| SCHEMBL12307456 | 0.83 | SMN1; SMN2 (0.33) | SMN1; SMN2GRM5HTR1DHTR1BHTR1F | |
| SCHEMBL12307452 | 0.83 | NPC1 (0.40) | SMN1; SMN2GRM5TP53 | |
| SCHEMBL12307397 | 0.82 | TP53 (0.38) | SMN1; SMN2GCKHTR1DHTR1BHTR1F | |
| SCHEMBL12307467 | 0.80 | KDM4E (0.40) | SMN1; SMN2HTR1DHTR1BHTR1F | |
| SCHEMBL12334300 | 0.79 | GRM5 (0.39) | SMN1; SMN2GRM5 | |
| SCHEMBL12307448 | 0.79 | GRM5 (0.32) | SMN1; SMN2GCKGRM5 | |
| SCHEMBL12307454 | 0.78 | TP53 (0.40) | GRM5TP53 | |
| SCHEMBL12334700 | 0.78 | SMN1; SMN2 (0.39) | SMN1; SMN2GCKHTR1DHTR1BHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230472-A1 | RING-FUSED AZOLE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2011-09-22 | — | — | US | disclosed |
| US-20110230472-A1 | RING-FUSED AZOLE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2011-09-22 | — | — | US | disclosed |
| EP-2327704-A1 | RING-FUSED AZOLE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY | Shionogi&Co., Ltd. (JP) | 2011-06-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230472-A1 | RING-FUSED AZOLE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY | PIK3R5, PIK3R4, PIK3R1 | SMN1; SMN2 3905/4885GCK 1876/4885GRM5 1849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.