Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 10/20 | 0.70 |
| ▸ | PIP4K2B | P78356 | 10/20 | 0.70 |
| ▸ | ITK | Q08881 | 3/20 | 0.57 |
| ▸ | EGFR | P00533 | 8/20 | 0.57 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.55 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL691105 | 0.90 | PIP4K2A (0.66) | PIP4K2APIP4K2BITKEGFRPIP4K2C | |
| SCHEMBL691106 | 0.90 | PIP4K2A (0.66) | PIP4K2APIP4K2BITKEGFRPIP4K2C | |
| SCHEMBL14773009 | 0.88 | PIP4K2A (0.64) | PIP4K2APIP4K2BITKEGFRJAK3 | |
| SCHEMBL690942 | 0.87 | PIP4K2A (0.76) | PIP4K2APIP4K2BITKEGFRJAK3 | |
| SCHEMBL690941 | 0.87 | PIP4K2A (0.76) | PIP4K2APIP4K2BITKEGFRJAK3 | |
| SCHEMBL12262340 | 0.83 | PIP4K2A (0.59) | PIP4K2APIP4K2BITKEGFRPIP4K2C | |
| SCHEMBL690518 | 0.83 | EGFR (0.61) | PIP4K2APIP4K2BEGFRERBB2ERBB4 | |
| SCHEMBL690519 | 0.83 | EGFR (0.61) | PIP4K2APIP4K2BEGFRERBB2ERBB4 | |
| SCHEMBL12510765 | 0.82 | EGFR (0.62) | PIP4K2APIP4K2BEGFRJAK3ERBB2 | |
| SCHEMBL690096 | 0.82 | PIP4K2A (0.72) | PIP4K2APIP4K2BITKEGFRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160311780-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RES INC (US) | 2016-10-27 | — | — | US | disclosed |
| US-20160311780-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RES INC (US) | 2016-10-27 | — | — | US | disclosed |
| US-8329901-B2 | 4,6-disubstitued pyrimidines useful as kinase inhibitors | CELGENE AVILOMICS RESEARCH, INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-20110224432-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2011-09-15 | — | — | US | disclosed |
| US-7982036-B2 | 4,6-disubstitued pyrimidines useful as kinase inhibitors | AVILA THERAPEUTICS, INC. (US) | 2011-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160311780-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | PIP4K2A 3115/4885PIP4K2B 2793/4885ITK 2697/4885 |
| US-20110224432-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | PIP4K2A 3115/4885PIP4K2B 2793/4885ITK 2697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.