Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.68 |
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776197 | 1.00 | MAP3K5 (0.68) | MAP3K5JAK2SMN1; SMN2ALDH1A1JAK1 | |
| SCHEMBL2787979 | 1.00 | MAP3K5 (0.68) | MAP3K5JAK2SMN1; SMN2ALDH1A1JAK1 | |
| Hydrochloric Acid SCHEMBL2773668 | 0.99 | MAP3K5 (0.67) | MAP3K5JAK2SMN1; SMN2ALDH1A1JAK1 | |
| SCHEMBL2787509 | 0.95 | MAP3K5 (0.74) | MAP3K5JAK2ALDH1A1JAK1TYK2 | |
| SCHEMBL2790274 | 0.91 | MAP3K5 (0.69) | MAP3K5JAK2ALDH1A1JAK1TYK2 | |
| SCHEMBL12317221 | 0.91 | MAP3K5 (0.69) | MAP3K5JAK2ALDH1A1JAK1TYK2 | |
| SCHEMBL2786313 | 0.90 | MAP3K5 (0.66) | MAP3K5JAK2SMN1; SMN2ALDH1A1JAK1 | |
| SCHEMBL2771646 | 0.90 | MAP3K5 (0.60) | MAP3K5JAK2SMN1; SMN2ALDH1A1JAK1 | |
| SCHEMBL2788673 | 0.89 | MAP3K5 (0.65) | MAP3K5JAK2SMN1; SMN2JAK1TYK2 | |
| SCHEMBL2787694 | 0.89 | JAK1 (0.53) | MAP3K5JAK2SMN1; SMN2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238565-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS | MERCK SERONO SA (CH) | 2012-09-20 | — | — | US | disclosed |
| US-8263595-B2 | Triazolopyridine compounds and their use as ask inhibitors | MERCK SERONO SA (CH) | 2012-09-11 | — | — | US | disclosed |
| US-20100197681-A1 | Triazolopyridine Compounds and Their Use as Ask Inhibitors | MERCK SERONO SA (CH) | 2010-08-05 | — | — | US | disclosed |
| WO-2009027283-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS | MERCK SERONO S.A. (CH) | 2009-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197681-A1 | Triazolopyridine Compounds and Their Use as Ask Inhibitors | MAP3K5, MAPKAPK5, MAP3K9 | MAP3K5 1/4885JAK2 228/4885SMN1; SMN2 3001/4885 |
| US-20120238565-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS | MAP3K5, MAPKAPK5, MAP3K9 | MAP3K5 1/4885JAK2 228/4885SMN1; SMN2 3001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.