Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 7/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | LDLR | P01130 | 1/20 | 0.36 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12318042 | 0.89 | AXL (0.58) | AXLPRMT5WDR77HTR6HTR1A | |
| SCHEMBL12318032 | 0.80 | IDO1 (0.50) | FGFR1HTR6HTR7HTR2AAURKA | |
| SCHEMBL12317927 | 0.79 | MAP2K4 (0.48) | PRMT5WDR77HTR6HTR1AHTR7 | |
| SCHEMBL12317929 | 0.76 | MAP2K4 (0.53) | HTR6HTR1AHTR7DRD2CYP3A4 | |
| SCHEMBL12318033 | 0.76 | LRRK2 (0.51) | FGFR1FGFR2 | |
| SCHEMBL12619759 | 0.74 | AXL (0.44) | AXLPRMT5WDR77PDPK1 | |
| SCHEMBL12318041 | 0.72 | IDO1 (0.38) | PRMT5WDR77FGFR1HTR6HTR1A | |
| SCHEMBL1663819 | 0.72 | FGFR1 (0.71) | AXLFGFR1FGFR2AURKACHEK1 | |
| SCHEMBL6371302 | 0.70 | AXL (1.00) | AXLFGFR1FGFR2AURKAIDO1 | |
| SCHEMBL5552470 | 0.69 | AXL (0.69) | AXLFGFR1FGFR2AURKACHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212961-A1 | Pyrazole Derivatives as Kinase Inhibitors | BURNHAM INSTITUTE FOR MEDICAL RESEARCH | 2011-09-01 | — | — | US | disclosed |
| US-7951832-B2 | Pyrazole derivatives as kinase inhibitors | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-05-31 | — | — | US | disclosed |
| US-20090124621-A1 | PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124621-A1 | PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | BRAF, MAP3K1, MAP3K3 | AXL 959/4885PRMT5 1089/4885WDR77 2169/4885 |
| US-20110212961-A1 | Pyrazole Derivatives as Kinase Inhibitors | BRAF, MAP3K1, MAP3K3 | AXL 959/4885PRMT5 1089/4885WDR77 2169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.