Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.67 |
| ▸ | CA2 | P00918 | 2/20 | 0.67 |
| ▸ | ACMSD | Q8TDX5 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | DHFR | P00374 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TTR | P02766 | 1/20 | 0.52 |
| ▸ | ALB | P02768 | 1/20 | 0.52 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.52 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.52 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.51 |
| ▸ | HNF4A | P41235 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL412559 | 0.84 | CA1 (0.71) | CA1CA2ACMSDALDH1A1HPGD | |
| SCHEMBL2403560 | 0.84 | CA1 (0.76) | CA1CA2ACMSDALDH1A1HPGD | |
| 5-Chlorosalicylic Acid SCHEMBL130605 | 0.82 | CA1 (1.00) | CA1CA2ACMSDALDH1A1HPGD | |
| 5-Chlorosalicylic Acid SCHEMBL29499764 | 0.82 | CA1 (1.00) | CA1CA2ACMSDALDH1A1HPGD | |
| 5-Chlorosalicylic Acid SCHEMBL6855770 | 0.80 | CA1 (0.96) | CA1CA2ACMSDALDH1A1HPGD | |
| 5-Chlorosalicylic Acid SCHEMBL27653659 | 0.80 | CA1 (0.96) | CA1CA2ACMSDALDH1A1HPGD | |
| 5-Chlorosalicylic Acid SCHEMBL943143 | 0.80 | CA1 (0.96) | CA1CA2ACMSDALDH1A1HPGD | |
| 5-Chlorosalicylic Acid SCHEMBL27653684 | 0.80 | CA1 (0.96) | CA1CA2ACMSDALDH1A1HPGD | |
| 5-Chlorosalicylic Acid SCHEMBL11158036 | 0.80 | CA1 (0.96) | CA1CA2ACMSDALDH1A1HPGD | |
| 5-Chlorosalicylic Acid SCHEMBL27673709 | 0.80 | CA1 (0.96) | CA1CA2ACMSDALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1988397-B1 | COMPOSITIONS AND USES FOR STABILISING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING | SCRIPPS RESEARCH INST (US) | 2011-09-14 | — | — | EP | disclosed |