Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 0.54 |
| ▸ | AKT2 | P31751 | 8/20 | 0.54 |
| ▸ | AKT3 | Q9Y243 | 8/20 | 0.54 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | AKT1S1 | Q96B36 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2265472 | 1.00 | AKT1 (0.54) | AKT1AKT2AKT3DPP4AKT1S1 | |
| SCHEMBL2265484 | 1.00 | AKT1 (0.54) | AKT1AKT2AKT3DPP4AKT1S1 | |
| SCHEMBL2259640 | 0.88 | DPP4 (0.43) | AKT1AKT2AKT3DPP4 | |
| SCHEMBL12324610 | 0.88 | DPP4 (0.43) | AKT1AKT2AKT3DPP4 | |
| SCHEMBL2259646 | 0.88 | DPP4 (0.43) | AKT1AKT2AKT3DPP4 | |
| SCHEMBL2263456 | 0.85 | AKT1 (0.54) | AKT1AKT2AKT3 | |
| SCHEMBL2263447 | 0.85 | AKT1 (0.54) | AKT1AKT2AKT3 | |
| SCHEMBL2266441 | 0.84 | AKT1 (0.53) | AKT1AKT2AKT3AKT1S1 | |
| SCHEMBL2266434 | 0.84 | AKT1 (0.53) | AKT1AKT2AKT3AKT1S1 | |
| SCHEMBL12324607 | 0.84 | AKT1 (0.61) | AKT1AKT2AKT3AKT1S1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049500-B1 | CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2011-09-07 | — | — | EP | disclosed |