Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL9317522 | 1.00 | HRH4 (0.35) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL2113040 | 1.00 | HRH4 (0.35) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL2407943 | 1.00 | HRH4 (0.35) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL8720072 | 1.00 | HRH4 (0.35) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL28152485 | 0.98 | HRH4 (0.34) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL2058267 | 0.98 | HRH4 (0.34) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL28942413 | 0.98 | HRH4 (0.34) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Histamine SCHEMBL29175699 | 0.96 | HRH1 (0.35) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| P-Xylene SCHEMBL28101363 | 0.91 | TAAR1 (0.38) | HRH4HRH3CYP2C9TSHRCYP2C19 | |
| Pyrophosphoric Acid SCHEMBL2113037 | 0.90 | TDP1 (0.32) | HRH4HRH3CYP2C9TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2723 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120023897-A | Preparation method and application method of sugar amine phosphorus-based wood modifier | 东北林业大学 | 2025-05-23 | — | — | CN | claimed |
| CN-119139217-A | Histamine sustained-release dopamine-hyaluronic acid injectable hydrogel, preparation method and application | 复旦大学附属中山医院 | 2024-12-17 | — | — | CN | claimed |
| CN-119074936-A | Medicine-carrying nano carbon dot for treating atherosclerosis and preparation method thereof | 四川大学 | 2024-12-06 | — | — | CN | claimed |
| CN-118419869-A | Bi (I) containing bismuth, phosphorus and nitrogen material, preparation method and application | 德清县浙工大莫干山研究院 | 2024-08-02 | — | — | CN | claimed |
| CN-116081616-B | Low-sulfur high-expansion-temperature expandable graphite and preparation method and application thereof | 湛江市聚鑫新能源有限公司 | 2024-06-11 | — | — | CN | claimed |
| CN-115895723-B | Method and system for continuously producing base oil from waste mineral oil containing chlorine and silicon | 宁波中循环保科技有限公司 | 2024-06-04 | — | — | CN | claimed |
| WO-2024092841-A1 | METHOD AND SYSTEM FOR CONTINUOUSLY PRODUCING BASE OIL FROM WASTE MINERAL OIL CONTAINING CHLORINE AND SILICON | 宁波中循环保科技有限公司 | 2024-05-10 | — | — | WO | claimed |
| CN-117842968-A | Biomass hard carbon sodium-electricity negative electrode material with enlarged interlayer spacing, preparation method and application | 福建容钠新能源科技有限公司 | 2024-04-09 | — | — | CN | claimed |
| CN-117752785-A | Histamine human immunoglobulin preparation and its preparing method | 华兰生物工程重庆有限公司 | 2024-03-26 | — | — | CN | claimed |
| EP-4294446-A1 | SYSTEMS, DEVICES, AND FORMULATIONS FOR TIME-PHASED HISTAMINE DELIVERY | Agonex Biopharmaceuticals, Inc. (US) | 2023-12-27 | — | — | EP | claimed |
| US-5261876-A | Enhanced peritoneal membrane plasmapheresis | MONCRIEF-POPOVICH RESEARCH INSTITUTE, INC. (US) | 1993-11-16 | — | — | US | claimed |
| US-5176912-A | Method of treating psoriasis | CABEZAS ORESTES (US) | 1993-01-05 | — | — | US | claimed |
| EP-0259438-A4 | METHODS AND MATERIALS FOR TREATMENT OF RHEUMATOID ARTHRITIS. | MCMICHAEL JOHN | 1989-09-11 | — | — | EP | claimed |
| EP-0094575-B1 | COMPOSITIONS FOR TREATMENT OF DISEASE STATES INVOLVING IMMUNOLOGICAL FACTORS | MCMICHAEL, John (US) | 1988-08-10 | — | — | EP | claimed |
| EP-0259438-A1 | METHODS AND MATERIALS FOR TREATMENT OF RHEUMATOID ARTHRITIS | MCMICHAEL, John (US) | 1988-03-16 | — | — | EP | claimed |
| US-4705685-A | Methods and materials for treatment of disease states involving immunological factors | SIGNAL COORDINATING THERAPY, INC. | 1987-11-10 | — | — | US | claimed |
| US-4704273-A | IMMUNOGLOBULIN G PROVOCATIVE OF PHEUMATOID FACTOR FORMATION | MOLECULAR RX, INC. | 1987-11-03 | — | — | US | claimed |
| WO-1987005221-A1 | METHODS AND MATERIALS FOR TREATMENT OF RHEUMATOID ARTHRITIS | MCMICHAEL JOHN | 1987-09-11 | — | — | WO | claimed |
| US-4521405-A | MIXTURE OF HISTAMINE AND MEASLES VIRUS IMMUNMOGEN | McMichael, John (US) | 1985-06-04 | — | — | US | claimed |
| EP-0094575-A2 | Compositions for treatment of disease states involving immunological factors | MCMICHAEL, John (US) | 1983-11-23 | — | — | EP | claimed |