Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 17/20 | 0.81 |
| ▸ | PLK3 | Q9H4B4 | 10/20 | 0.81 |
| ▸ | PLK2 | Q9NYY3 | 9/20 | 0.81 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.80 |
| ▸ | CLK2 | P49760 | 3/20 | 0.80 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.80 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.80 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.80 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.80 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.80 |
| ▸ | CSNK1G3 | Q9Y6M4 | 3/20 | 0.80 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.80 |
| ▸ | PRKCG | P05129 | 2/20 | 0.80 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.80 |
| ▸ | NEK4 | P51957 | 2/20 | 0.80 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.80 |
| ▸ | BRD4 | O60885 | 9/20 | 0.76 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.76 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.76 |
| ▸ | TAF1 | P21675 | 3/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12324591 | 1.00 | PLK1 (0.81) | PLK1PLK3PLK2PRKD3CLK2 | |
| SCHEMBL375839 | 0.93 | PLK1 (0.86) | PLK1PLK3PLK2PRKD3CLK2 | |
| SCHEMBL376821 | 0.91 | PLK1 (0.92) | PLK1PLK3PLK2PRKD3CLK2 | |
| SCHEMBL30750574 | 0.91 | PLK1 (0.92) | PLK1PLK3PLK2PRKD3CLK2 | |
| SCHEMBL25767082 | 0.91 | PLK1 (0.90) | PLK1PLK3PLK2PRKD3CLK2 | |
| SCHEMBL30750517 | 0.90 | PLK1 (0.82) | PLK1PLK3PLK2PRKD3CLK2 | |
| SCHEMBL12323286 | 0.90 | PLK1 (0.86) | PLK1PLK3PLK2PRKD3CLK2 | |
| SCHEMBL12323789 | 0.90 | PLK1 (0.86) | PLK1PLK3PLK2PRKD3CLK2 | |
| SCHEMBL12323269 | 0.90 | PLK1 (0.86) | PLK1PLK3PLK2PRKD3CLK2 | |
| SCHEMBL30750540 | 0.90 | PLK1 (0.81) | PLK1PLK3PLK2PRKD3CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011113293-A1 | DIHYDROPTERIDINONE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 江苏恒瑞医药股份有限公司 (CN) | 2011-09-22 | — | — | WO | disclosed |