Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 3/20 | 0.42 |
| ▸ | XIAP | P98170 | 11/20 | 0.40 |
| ▸ | BIRC3 | Q13489 | 9/20 | 0.40 |
| ▸ | BIRC2 | Q13490 | 4/20 | 0.36 |
| ▸ | BIRC7 | Q96CA5 | 1/20 | 0.36 |
| ▸ | CASP9 | P55211 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2440956 | 1.00 | TNF (0.42) | TNFXIAPBIRC3BIRC2BIRC7 | |
| SCHEMBL12299766 | 1.00 | TNF (0.42) | TNFXIAPBIRC3BIRC2BIRC7 | |
| SCHEMBL13448822 | 0.91 | XIAP (0.43) | TNFXIAPBIRC3BIRC2BIRC7 | |
| SCHEMBL12299769 | 0.91 | XIAP (0.43) | TNFXIAPBIRC3BIRC2BIRC7 | |
| SCHEMBL2445027 | 0.91 | XIAP (0.43) | TNFXIAPBIRC3BIRC2BIRC7 | |
| SCHEMBL12329391 | 0.91 | XIAP (0.43) | TNFXIAPBIRC3BIRC2BIRC7 | |
| SCHEMBL2442674 | 0.90 | TNF (0.42) | TNFXIAPBIRC3BIRC2BIRC7 | |
| SCHEMBL12299874 | 0.90 | TNF (0.42) | TNFXIAPBIRC3BIRC2BIRC7 | |
| SCHEMBL12329407 | 0.89 | XIAP (0.39) | TNFXIAPBIRC3BIRC2BIRC7 | |
| SCHEMBL2441070 | 0.89 | XIAP (0.43) | TNFXIAPBIRC3BIRC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399683-B2 | IAP inhibitors | TETRALOGIC PHARMACEUTICALS (US) | 2013-03-19 | — | — | US | disclosed |
| US-20110237517-A1 | IAP INHIBITORS | TETRALOGIC PHARMACEUTICALS CORP. | 2011-09-29 | — | — | US | disclosed |
| WO-2010033531-A1 | IAP INHIBITORS | TETRALOGIC PHARMACEUTICALS CORP. (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237517-A1 | IAP INHIBITORS | XIAP, IAPP, BIRC5 | TNF 97/4885XIAP 1/4885BIRC3 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.