Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 20/20 | 0.65 |
| ▸ | JAK2 | O60674 | 19/20 | 0.65 |
| ▸ | JAK3 | P52333 | 19/20 | 0.65 |
| ▸ | TYK2 | P29597 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12333267 | 1.00 | JAK1 (0.65) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2377455 | 0.86 | JAK1 (0.88) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2378875 | 0.86 | JAK1 (0.88) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL18720813 | 0.84 | JAK1 (0.71) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL18720804 | 0.82 | JAK1 (0.65) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL18720810 | 0.82 | JAK1 (0.65) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL18732888 | 0.82 | JAK1 (0.65) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL18720770 | 0.81 | JAK1 (0.65) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL18720795 | 0.80 | JAK1 (0.79) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL1368278 | 0.80 | JAK1 (0.86) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011117145-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-29 | — | — | WO | disclosed |