Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | HCK | P08631 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12333441 | 0.83 | JAK2 (0.62) | JAK2KCNH2CHEK1 | |
| SCHEMBL2460323 | 0.80 | JAK2 (0.60) | JAK2KCNH2CHEK1IKBKBMAPK13 | |
| SCHEMBL2455509 | 0.80 | JAK2 (0.59) | JAK2KCNH2CHEK1IKBKBMAPK13 | |
| SCHEMBL2459196 | 0.80 | JAK2 (0.67) | JAK2KCNH2CHEK1 | |
| SCHEMBL2458089 | 0.80 | JAK2 (0.68) | JAK2KCNH2CHEK1IKBKBMAPK13 | |
| SCHEMBL13297085 | 0.79 | JAK2 (0.55) | JAK2KCNH2CHEK1 | |
| SCHEMBL2457884 | 0.79 | JAK2 (0.80) | JAK2KCNH2CHEK1 | |
| SCHEMBL2457731 | 0.77 | JAK2 (1.00) | JAK2KCNH2 | |
| SCHEMBL2460645 | 0.77 | JAK2 (0.64) | JAK2KCNH2CHEK1IKBKBMAPK13 | |
| SCHEMBL2458061 | 0.76 | JAK2 (0.64) | JAK2KCNH2CHEK1IKBKBMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134346-B1 | INHIBITORS OF JANUS KINASES AND/OR 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 | MERCK SHARP & DOHME (US) | 2011-09-21 | — | — | EP | disclosed |