Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 3/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12110375 | 0.84 | MAPK1 (0.45) | CRBNESR2MAPK1NR1H2USP30 | |
| SCHEMBL1293437 | 0.83 | ESR2 (0.43) | CRBNESR2MAPK1NR1H2DDB1 | |
| SCHEMBL1294501 | 0.82 | ESR2 (0.45) | CRBNESR2MAPK1NR1H2DDB1 | |
| SCHEMBL18648638 | 0.82 | ESR2 (0.41) | CRBNESR2MAPK1NR1H2USP30 | |
| SCHEMBL12110094 | 0.78 | USP30 (0.41) | CRBNESR2MAPK1NR1H2USP30 | |
| SCHEMBL12106038 | 0.76 | CKS1B (0.38) | ESR2NR1H2USP30KITUCHL1 | |
| SCHEMBL14115666 | 0.76 | ESR2 (0.49) | ESR2MAPK1NR1H2UCHL1CKS1B | |
| SCHEMBL1294136 | 0.75 | ESR2 (0.50) | CRBNESR2MAPK1NR1H2DDB1 | |
| SCHEMBL12110154 | 0.74 | ESR2 (0.40) | CRBNESR2MAPK1NR1H2USP30 | |
| SCHEMBL12110033 | 0.74 | MAPK1 (0.39) | CRBNESR2MAPK1NR1H2UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011111817-A1 | BENZAZEPINE COMPOUND | アステラス製薬株式会社 (JP) | 2011-09-15 | — | — | WO | disclosed |