Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINA3 | P01011 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | BTN3A1 | O00481 | 8/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | PRKACG | P22612 | 1/20 | 0.34 |
| ▸ | PRKACB | P22694 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2734872 | 0.94 | POLB (0.41) | SERPINA3POLBBTN3A1HDAC1CDK1 | |
| SCHEMBL14621938 | 0.94 | POLB (0.41) | SERPINA3POLBBTN3A1HDAC1CDK1 | |
| SCHEMBL12343771 | 0.93 | POLB (0.42) | SERPINA3POLBHDAC1CDK1PRKACA | |
| SCHEMBL14621731 | 0.92 | POLB (0.40) | SERPINA3POLBBTN3A1HDAC1CDK1 | |
| SCHEMBL14621992 | 0.92 | POLB (0.40) | SERPINA3POLBBTN3A1HDAC1CDK1 | |
| SCHEMBL2734871 | 0.91 | HDAC1 (0.41) | SERPINA3POLBBTN3A1HDAC1CDK1 | |
| SCHEMBL14621994 | 0.91 | HDAC1 (0.41) | SERPINA3POLBBTN3A1HDAC1CDK1 | |
| SCHEMBL14621501 | 0.90 | HDAC1 (0.41) | SERPINA3POLBBTN3A1HDAC1HDAC2 | |
| SCHEMBL2734873 | 0.90 | HDAC1 (0.41) | SERPINA3POLBBTN3A1HDAC1HDAC2 | |
| SCHEMBL14621724 | 0.89 | POLB (0.42) | SERPINA3POLBHDAC1CDK1PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268802-B2 | Anti-proliferative compounds, compositions, and methods of use thereof | GILEAD SCIENCES, INC. (US) | 2012-09-18 | — | — | US | disclosed |