Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | SERPINA3 | P01011 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | PRKACG | P22612 | 1/20 | 0.39 |
| ▸ | PRKACB | P22694 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | POLA1 | P09884 | 2/20 | 0.36 |
| ▸ | POLG | P54098 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14621775 | 1.00 | POLB (0.46) | POLBSERPINA3CDK1PRKACACCNA2 | |
| SCHEMBL2734863 | 0.93 | POLB (0.46) | POLBSERPINA3CDK1PRKACACCNA2 | |
| SCHEMBL14621772 | 0.93 | POLB (0.46) | POLBSERPINA3CDK1PRKACACCNA2 | |
| SCHEMBL14621760 | 0.92 | POLB (0.44) | POLBSERPINA3CDK1PRKACACCNA2 | |
| SCHEMBL14621492 | 0.91 | POLB (0.45) | POLBSERPINA3CDK1PRKACACCNA2 | |
| SCHEMBL14621990 | 0.91 | POLB (0.45) | POLBSERPINA3CDK1PRKACACCNA2 | |
| SCHEMBL10167597 | 0.91 | POLB (0.47) | POLBSERPINA3CDK1PRKACACCNA2 | |
| SCHEMBL2734860 | 0.90 | POLB (0.44) | POLBSERPINA3CDK1PRKACACCNA2 | |
| SCHEMBL14621500 | 0.90 | POLB (0.44) | POLBSERPINA3CDK1PRKACACCNA2 | |
| SCHEMBL14621721 | 0.88 | POLB (0.45) | POLBSERPINA3CDK1PRKACACCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268802-B2 | Anti-proliferative compounds, compositions, and methods of use thereof | GILEAD SCIENCES, INC. (US) | 2012-09-18 | — | — | US | disclosed |