Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 8/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 5/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCND2 | P30279 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | PAK3 | O75914 | 1/20 | 0.37 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.37 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1227459 | 1.00 | MAPK8 (0.42) | MAPK8MAPK10MAPK9MAPK14CNR2 | |
| SCHEMBL1227248 | 0.91 | MAP4K1 (0.41) | MAPK8MAPK10MAPK9MAPK14CNR2 | |
| SCHEMBL12340361 | 0.91 | MAP4K1 (0.41) | MAPK8MAPK10MAPK9MAPK14CNR2 | |
| SCHEMBL4299090 | 0.88 | CCND1 (0.47) | MAPK8MAPK10MAPK9MAPK14CDK4 | |
| SCHEMBL3305221 | 0.83 | CCND1 (0.57) | MAPK8MAPK10MAPK9MAPK14CDK4 | |
| SCHEMBL7794858 | 0.83 | CCND1 (0.57) | MAPK8MAPK10MAPK9MAPK14CDK4 | |
| SCHEMBL4300505 | 0.80 | MAPK8 (0.55) | MAPK8MAPK10MAPK9CDK4CCND1 | |
| SCHEMBL12340363 | 0.80 | MAPK8 (0.55) | MAPK8MAPK10MAPK9CDK4CCND1 | |
| SCHEMBL1227177 | 0.80 | MAPK8 (0.55) | MAPK8MAPK10MAPK9CDK4CCND1 | |
| SCHEMBL1227169 | 0.79 | MAPK8 (0.54) | MAPK8MAPK10MAPK9CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268840-B2 | Pyrimidinyl pyridone inhibitors of kinases | ROCHE PALO ALTO LLC (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268840-B2 | Pyrimidinyl pyridone inhibitors of kinases | ROCHE PALO ALTO LLC (US) | 2012-09-18 | — | — | US | disclosed |
| US-20090270389-A1 | Pyrimidinyl pyridone inhibitors of kinases | ROCHE PALO ALTO LLC | 2009-10-29 | — | — | US | disclosed |
| US-20090270389-A1 | Pyrimidinyl pyridone inhibitors of kinases | ROCHE PALO ALTO LLC | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270389-A1 | Pyrimidinyl pyridone inhibitors of kinases | MAP3K1, MAP3K20, MAP3K6 | MAPK8 37/4885MAPK10 42/4885MAPK9 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.