Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.57 |
| ▸ | PSMB5 | P28074 | 13/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.35 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.34 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.34 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.34 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.34 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.34 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.34 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.34 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.34 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.34 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.34 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.34 |
| ▸ | LONP1 | P36776 | 1/20 | 0.34 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15028164 | 0.87 | PSMB5 (0.43) | DPP4PSMB5ANPEPPSMB8PSMB1 | |
| SCHEMBL12340801 | 0.79 | PSMB5 (0.47) | PSMB5PSMB8PSMB1 | |
| SCHEMBL12340810 | 0.77 | PSMB5 (0.44) | DPP4PSMB5ANPEPPSMB8PSMB1 | |
| SCHEMBL12340797 | 0.77 | DPP8 (0.62) | DPP4PSMB5PSMB8DPP8DPP7 | |
| SCHEMBL12340805 | 0.75 | PSMB5 (0.57) | PSMB5PSMB8PSMB1CTRB1PSMB2 | |
| SCHEMBL15028118 | 0.73 | DPP4 (1.00) | DPP4ANPEPDPP8DPP7 | |
| SCHEMBL12340738 | 0.73 | DPP4 (1.00) | DPP4ANPEPDPP8DPP7 | |
| SCHEMBL10952773 | 0.69 | PSMB5 (0.56) | PSMB5PSMB8PSMB1CTRB1PSMB11 | |
| SCHEMBL12340807 | 0.69 | PSMB5 (0.60) | PSMB5PSMB8PSMB1PSMB11PSMA7 | |
| SCHEMBL21558113 | 0.68 | PSMB5 (0.54) | PSMB5PSMB8PSMB1PSMB11PSMA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160250237-A1 | SOFT PROTEASE INHIBITORS AND PRO-SOFT FORMS THEREOF | BACH BIOSCIENCES, LLC | 2016-09-01 | — | — | US | disclosed |
| US-9192646-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2015-11-24 | — | — | US | disclosed |
| US-20150157684-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | BACH BIOSCIENCES, LLC | 2015-06-11 | — | — | US | disclosed |
| US-8933056-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2015-01-13 | — | — | US | disclosed |
| US-20140128344-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2014-05-08 | — | — | US | disclosed |
| US-8563533-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2013-10-22 | — | — | US | disclosed |
| US-8268880-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268880-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2012-09-18 | — | — | US | disclosed |
| US-20090124559-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | TRUSTEES OF TUFTS COLLEGE OFFICE OF TECHNOLOGY AND INDUSTRY COLLABORATION (US) | 2009-05-14 | — | — | US | disclosed |
| US-20090124559-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | TRUSTEES OF TUFTS COLLEGE OFFICE OF TECHNOLOGY AND INDUSTRY COLLABORATION (US) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124559-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | PREP, DPP4, PEPD | DPP4 2/4885PSMB5 142/4885ANPEP 15/4885 |
| US-20160250237-A1 | SOFT PROTEASE INHIBITORS AND PRO-SOFT FORMS THEREOF | PREP, DPP4, PEPD | DPP4 2/4885PSMB5 142/4885ANPEP 15/4885 |
| US-20150157684-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | PREP, DPP4, PEPD | DPP4 2/4885PSMB5 142/4885ANPEP 15/4885 |
| US-20140128344-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | PREP, DPP4, PEPD | DPP4 2/4885PSMB5 142/4885ANPEP 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.