Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 19/20 | 0.60 |
| ▸ | DPP7 | Q9UHL4 | 14/20 | 0.60 |
| ▸ | DPP8 | Q6V1X1 | 12/20 | 0.60 |
| ▸ | DPP9 | Q86TI2 | 11/20 | 0.60 |
| ▸ | FAP | Q12884 | 10/20 | 0.60 |
| ▸ | PREP | P48147 | 5/20 | 0.46 |
| ▸ | PITRM1 | Q5JRX3 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12344393 | 0.97 | DPP4 (0.58) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL15386479 | 0.91 | DPP4 (0.67) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL13263365 | 0.91 | DPP4 (0.67) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL12658525 | 0.88 | DPP4 (0.65) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL12658428 | 0.88 | DPP4 (0.65) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL15028072 | 0.85 | DPP4 (0.58) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL15028138 | 0.85 | DPP4 (0.45) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL15386482 | 0.85 | DPP4 (0.70) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL12658521 | 0.85 | DPP4 (0.70) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL13285827 | 0.82 | DPP4 (0.65) | DPP4DPP7DPP8DPP9FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563533-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2013-10-22 | — | — | US | disclosed |
| US-20130150292-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2013-06-13 | — | — | US | disclosed |
| US-8268880-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2012-09-18 | — | — | US | disclosed |
| US-20090124559-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | TRUSTEES OF TUFTS COLLEGE OFFICE OF TECHNOLOGY AND INDUSTRY COLLABORATION (US) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150292-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | PREP, DPP4, PEPD | DPP4 2/4885DPP7 8/4885DPP8 13/4885 |
| US-20090124559-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | PREP, DPP4, PEPD | DPP4 2/4885DPP7 8/4885DPP8 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.