Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 6/20 | 0.63 |
| ▸ | VRK1 | Q99986 | 13/20 | 0.53 |
| ▸ | VRK2 | Q86Y07 | 2/20 | 0.53 |
| ▸ | RPS6KA6 | Q9UK32 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.53 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.53 |
| ▸ | STK4 | Q13043 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14457014 | 0.91 | RPS6KA3 (0.65) | RPS6KA3VRK1VRK2RPS6KA6JAK2 | |
| SCHEMBL14941101 | 0.85 | RPS6KA3 (0.61) | RPS6KA3VRK1VRK2RPS6KA6JAK2 | |
| SCHEMBL17780574 | 0.77 | RPS6KA3 (0.64) | RPS6KA3VRK1VRK2RPS6KA6JAK2 | |
| SCHEMBL17780459 | 0.77 | RPS6KA3 (0.54) | RPS6KA3VRK1VRK2RPS6KA6JAK2 | |
| SCHEMBL16160969 | 0.73 | RPS6KA3 (0.67) | RPS6KA3VRK1VRK2RPS6KA6JAK2 | |
| SCHEMBL862198 | 0.72 | RPS6KA3 (0.62) | RPS6KA3VRK1VRK2RPS6KA6JAK2 | |
| SCHEMBL21527053 | 0.72 | RPS6KA3 (0.62) | RPS6KA3VRK1VRK2RPS6KA6JAK2 | |
| SCHEMBL14972118 | 0.71 | RPS6KA3 (0.64) | RPS6KA3VRK1VRK2RPS6KA6JAK2 | |
| SCHEMBL17780318 | 0.70 | RPS6KA3 (0.58) | RPS6KA3VRK1VRK2RPS6KA6JAK2 | |
| SCHEMBL30013787 | 0.70 | VRK1 (1.00) | RPS6KA3VRK1VRK2RPS6KA6JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776363-B1 | NOVEL 6-FORMYLTETRAHYDROPTERIDINES METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT AGAINST CANCER AMONGST OTHER THINGS | BOEHRINGER INGELHEIM INT (DE) | 2012-09-19 | — | — | EP | disclosed |