Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetracycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | USP2 | O75604 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | RECQL | P46063 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | THRB | P10828 | 4/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetracycline SCHEMBL4932253 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL12856676 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Epitetracycline SCHEMBL19771301 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL2614976 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL16302914 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL13223984 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL6666071 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL4932271 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL21900130 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT | |
| Tetracycline SCHEMBL12247641 | 1.00 | MEN1 (0.70) | MEN1KMT2ATDP1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8007996-B2 | Methods to identify protein arginine deiminase 4 inhibitors | UNIVERSITY OF SOUTH CAROLINA (US) | 2011-08-30 | — | — | US | disclosed |
| US-8007996-B2 | Methods to identify protein arginine deiminase 4 inhibitors | UNIVERSITY OF SOUTH CAROLINA (US) | 2011-08-30 | — | — | US | disclosed |