Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 2/20 | 0.40 |
| ▸ | FADS1 | O60427 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12358859 | 0.88 | TRPV1 (0.42) | HDAC6CHEK2BRD4MAPTSMN1; SMN2 | |
| SCHEMBL12358695 | 0.86 | SCD (0.52) | NPC1RAB9AKMT2AMEN1SCD | |
| SCHEMBL1797468 | 0.85 | NTRK1 (0.43) | BRD4NPC1RAB9A | |
| SCHEMBL1796929 | 0.85 | TRPV1 (0.59) | BRD4 | |
| SCHEMBL1797926 | 0.85 | TRPV1 (0.43) | HDAC6BRD4MAPTTP53 | |
| SCHEMBL1796931 | 0.85 | TRPV1 (0.59) | BRD4 | |
| SCHEMBL1798025 | 0.82 | BRD4 (0.41) | BRD4MAPT | |
| SCHEMBL12359119 | 0.82 | KMT2A (0.53) | HDAC6CHEK2BRD4MAPTSMN1; SMN2 | |
| SCHEMBL12359107 | 0.82 | KDM4E (0.45) | CHEK2MAPTSMN1; SMN2TP53NPC1 | |
| SCHEMBL12358817 | 0.81 | HDAC6 (0.48) | HDAC6CHEK2BRD4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190344-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190344-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | VRK1, VRK2, VIL1 | HDAC6 2116/4885CHEK2 3484/4885BRD4 405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.