Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.34 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | APOB | P04114 | 2/20 | 0.31 |
| ▸ | MTTP | P55157 | 2/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1795392 | 0.90 | KDM1A (0.39) | KDM1AHSPD1HSPE1BRD4IDO1 | |
| SCHEMBL1799444 | 0.87 | KDM1A (0.42) | KDM1AHSPD1HSPE1BRD4IDO1 | |
| SCHEMBL1800685 | 0.86 | TRPV1 (0.42) | KDM1AHSPD1HSPE1BRD4IDO1 | |
| SCHEMBL1801600 | 0.85 | KDM1A (0.42) | KDM1AHSPD1HSPE1BRD4TRPV1 | |
| SCHEMBL12358812 | 0.84 | SCD (0.36) | ROCK2HCRTR1HCRTR2HTR2B | |
| SCHEMBL1796718 | 0.84 | KDM1A (0.38) | KDM1AHSPD1HSPE1BRD4IDO1 | |
| SCHEMBL12358861 | 0.84 | MAPT (0.42) | HSPD1HSPE1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL1799974 | 0.84 | KDM1A (0.46) | KDM1ABRD4TRPV1ALOX5APFEN1 | |
| SCHEMBL1798976 | 0.83 | KDM1A (0.43) | KDM1ABRD4TRPV1ALOX5APFEN1 | |
| SCHEMBL1799568 | 0.81 | ALOX5AP (0.38) | KDM1ABRD4IDO1TRPV1ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190344-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190344-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | VRK1, VRK2, VIL1 | KDM1A 1102/4885HSPD1 3190/4885HSPE1 2948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.