Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 11/20 | 0.80 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.80 |
| ▸ | HDAC4 | P56524 | 14/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.62 |
| ▸ | MEF2D | Q14814 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1236290 | 1.00 | HDAC3 (0.80) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL29392550 | 0.89 | HDAC1 (1.00) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL29354058 | 0.89 | HDAC1 (1.00) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL675746 | 0.89 | HDAC1 (1.00) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL675747 | 0.89 | HDAC1 (1.00) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL19383008 | 0.85 | HDAC1 (0.67) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL11974531 | 0.85 | HDAC3 (0.80) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL25049810 | 0.84 | HDAC1 (0.74) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL392628 | 0.83 | HDAC3 (0.77) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL11984101 | 0.82 | HDAC1 (0.76) | HDAC3HDAC1HDAC4HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10059657-B2 | Class-and isoform-specific HDAC inhibitors and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-08-28 | — | — | US | disclosed |
| US-20170267630-A1 | CLASS-AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-09-21 | — | — | US | disclosed |
| US-9540317-B2 | Class- and isoform-specific HDAC inhibitors and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-01-10 | — | — | US | disclosed |
| US-20150307444-A1 | CLASS- AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-10-29 | — | — | US | disclosed |
| US-8716344-B2 | Class- and isoform-specific HDAC inhibitors and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-05-06 | — | — | US | disclosed |
| US-20120208889-A1 | CLASS- AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUE, INC. (US) | 2012-08-16 | — | — | US | disclosed |
| WO-2011019393-A2 | CLASS- AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307444-A1 | CLASS- AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF | HDAC1, HDAC5, HDAC6 | HDAC3 4/4885HDAC1 1/4885HDAC4 8/4885 |
| US-20120208889-A1 | CLASS- AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF | HDAC1, HDAC5, HDAC6 | HDAC3 4/4885HDAC1 1/4885HDAC4 8/4885 |
| US-20170267630-A1 | CLASS-AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF | HDAC1, HDAC5, HDAC6 | HDAC3 4/4885HDAC1 1/4885HDAC4 8/4885 |
| US-10059657-B2 | Class-and isoform-specific HDAC inhibitors and uses thereof | HDAC1, HDAC5, HDAC6 | HDAC3 4/4885HDAC1 1/4885HDAC4 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.