Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10192187 | 0.82 | TP53 (0.64) | TP53POLBCDK1CDK2CDK4 | |
| SCHEMBL10053513 | 0.81 | CA1 (0.54) | TP53POLBCA1CA2CA6 | |
| SCHEMBL10053487 | 0.78 | POLB (0.62) | TP53POLBCA1CA2CA6 | |
| SCHEMBL3542897 | 0.77 | CA1 (0.58) | TP53POLBCA1CA2CA6 | |
| SCHEMBL8358594 | 0.76 | CA1 (0.61) | TP53POLBCA1CA2CA6 | |
| SCHEMBL23601605 | 0.74 | CA1 (0.42) | TP53CA1CA2CA6OPRK1 | |
| SCHEMBL15683644 | 0.74 | CA1 (0.59) | TP53POLBCA1CA2CA6 | |
| SCHEMBL23601599 | 0.74 | TP53 (0.53) | TP53POLBCA1CA2CA6 | |
| SCHEMBL22033248 | 0.73 | TP53 (0.51) | TP53PIK3C3 | |
| SCHEMBL7969768 | 0.73 | CA1 (0.50) | TP53POLBCA1CA2CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110195978-A1 | COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | PURDUE RESEARCH FOUNDATION (US) | 2011-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195978-A1 | COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | PSEN2, PSEN1, CHAT | TP53 2624/4885POLB 1818/4885CA1 409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.