Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.49 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.48 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | PYGL | P06737 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11305715 | 0.83 | TSHR (0.69) | TSHRTRPV1SMN1; SMN2LMNATP53 | |
| SCHEMBL12366142 | 0.82 | KMT2A (0.59) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL31248395 | 0.80 | TSHR (0.65) | TSHRTRPV1SMN1; SMN2LMNATP53 | |
| SCHEMBL4035255 | 0.80 | TSHR (0.65) | TSHRTRPV1SMN1; SMN2LMNATP53 | |
| SCHEMBL13683247 | 0.80 | TSHR (0.65) | TSHRTRPV1SMN1; SMN2LMNATP53 | |
| SCHEMBL5653386 | 0.79 | TSHR (0.63) | TSHRTRPV1SMN1; SMN2LMNATP53 | |
| SCHEMBL7937579 | 0.79 | TSHR (0.63) | TSHRTRPV1SMN1; SMN2LMNATP53 | |
| SCHEMBL30259914 | 0.79 | TSHR (0.68) | TSHRTRPV1SMN1; SMN2LMNATP53 | |
| SCHEMBL6361222 | 0.79 | TSHR (0.68) | TSHRTRPV1SMN1; SMN2LMNATP53 | |
| SCHEMBL3143102 | 0.79 | TSHR (0.63) | TSHRTRPV1SMN1; SMN2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |