⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526442 | 0.75 | — | — | |
| SCHEMBL24613135 | 0.71 | CETP (0.52) | — | |
| SCHEMBL7347552 | 0.71 | TSHR (0.42) | — | |
| SCHEMBL23949233 | 0.71 | CETP (0.52) | — | |
| SCHEMBL7347545 | 0.71 | TSHR (0.42) | — | |
| SCHEMBL891950 | 0.68 | CHRM1 (0.41) | — | |
| SCHEMBL891958 | 0.68 | RNPEP (0.38) | — | |
| SCHEMBL23949232 | 0.68 | HTT (0.32) | — | |
| Trifluoroacetic Acid SCHEMBL20539407 | 0.68 | CETP (0.48) | — | |
| Trifluoroacetic Acid SCHEMBL30671764 | 0.68 | GRIK1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10149644-B2 | Curcumin derivatives for amyloid-β plaque imaging | THE GENERAL HOSPITAL CORPORATION (US) | 2018-12-11 | — | — | US | disclosed |
| US-9757477-B2 | Imaging brown adipose tissue with curcumin derivatives | THE GENERAL HOSPITAL CORPORATION (US) | 2017-09-12 | — | — | US | disclosed |
| US-20160193363-A1 | Imaging Brown Adipose Tissue with Curcumin Derivatives | THE GENERAL HOSPITAL CORPORATION | 2016-07-07 | — | — | US | disclosed |
| US-20150087937-A1 | CURCUMIN DERIVATIVES FOR AMYLOID-BETA PLAQUE IMAGING | MASSACHUSETTS GENERAL HOSPITAL (US) | 2015-03-26 | — | — | US | disclosed |
| US-8986657-B2 | Methods and system for detecting soluble amyloid-β | THE GENERAL HOSPITAL CORPORATION (US) | 2015-03-24 | — | — | US | disclosed |
| WO-2015034996-A1 | IMAGING BROWN ADIPOSE TISSUE WITH CURCUMIN DERIVATIVES | THE GENERAL HOSPITAL CORPORATION (US) | 2015-03-12 | — | — | WO | disclosed |
| US-20120183474-A1 | Methods and System for Detecting Soluble Amyloid-Beta | THE GENERAL HOSPITAL CORPORATION | 2012-07-19 | — | — | US | disclosed |
| US-20110208064-A1 | Curcumin Derivatives for Amyloid-Beta Plaque Imaging | THE GENERAL HOSPITAL CORPORATION | 2011-08-25 | — | — | US | disclosed |
| WO-2011014648-A2 | METHODS AND SYSTEM FOR DETECTING SOLUBLE AMYLOID-β | THE GENERAL HOSPITAL CORPORATION (US) | 2011-02-03 | — | — | WO | disclosed |
| WO-2010017094-A2 | CURCUMIN DERIVATIVES FOR AMYLOID-β PLAQUE IMAGING | THE GENERAL HOSPITAL CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |