Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.55 |
| ▸ | SMO | Q99835 | 10/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2271431 | 1.00 | KDR (0.55) | KDRSMOALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2271428 | 1.00 | KDR (0.55) | KDRSMOALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2279994 | 0.94 | KDR (0.55) | KDRSMOMEN1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2279986 | 0.94 | KDR (0.55) | KDRSMOMEN1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2275092 | 0.93 | SMO (0.58) | KDRSMOALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2275086 | 0.93 | SMO (0.58) | KDRSMOALDH1A1MEN1KMT2A | |
| SCHEMBL12371944 | 0.93 | SMO (0.58) | KDRSMOALDH1A1MEN1KMT2A | |
| SCHEMBL12371951 | 0.93 | KDR (0.56) | KDRSMOMEN1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2278583 | 0.90 | SMO (0.63) | KDRSMO | |
| Hydrochloric Acid SCHEMBL2278585 | 0.90 | SMO (0.63) | KDRSMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404687-B2 | Disubstituted phthalazine hedgehog pathway antagonists | ELI LILLY AND COMPANY (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404687-B2 | Disubstituted phthalazine hedgehog pathway antagonists | ELI LILLY AND COMPANY (US) | 2013-03-26 | — | — | US | disclosed |
| US-20110190304-A1 | DISUBSTITUTED PHTHALAZINE HEDGEHOG PATHWAY ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-08-04 | — | — | US | disclosed |
| US-20110190304-A1 | DISUBSTITUTED PHTHALAZINE HEDGEHOG PATHWAY ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-08-04 | — | — | US | disclosed |
| WO-2010062507-A1 | DISUBSTITUTED PHTHALAZINE HEDGEHOG PATHWAY ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2010-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190304-A1 | DISUBSTITUTED PHTHALAZINE HEDGEHOG PATHWAY ANTAGONISTS | SHH, GLI1, SMO | KDR 1085/4885SMO 3/4885ALDH1A1 2679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.