Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | JAK3 | P52333 | 3/20 | 0.57 |
| ▸ | JAK2 | O60674 | 2/20 | 0.57 |
| ▸ | JAK1 | P23458 | 2/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | NEK2 | P51955 | 3/20 | 0.42 |
| ▸ | ULK1 | O75385 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2280444 | 1.00 | SYK (0.69) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2275553 | 0.91 | SYK (0.67) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2276501 | 0.87 | SYK (0.65) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2277141 | 0.86 | SYK (0.64) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2349493 | 0.86 | SYK (0.55) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2273835 | 0.86 | SYK (0.65) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2279703 | 0.83 | SYK (0.65) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2278561 | 0.82 | SYK (0.62) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2272838 | 0.82 | SYK (0.62) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL2279898 | 0.82 | SYK (0.62) | SYKCYP2C9JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008298-B2 | Pyrrolopyrazine kinase inhibitors | Roche Palo Alto (US) | 2011-08-30 | — | — | US | disclosed |
| US-8008298-B2 | Pyrrolopyrazine kinase inhibitors | Roche Palo Alto (US) | 2011-08-30 | — | — | US | disclosed |
| US-20100267666-A1 | Pyrrolopyrazine kinase inhibitors | ROCHE PALO ALTO LLC | 2010-10-21 | — | — | US | disclosed |
| US-20100267666-A1 | Pyrrolopyrazine kinase inhibitors | ROCHE PALO ALTO LLC | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267666-A1 | Pyrrolopyrazine kinase inhibitors | SYK, ZAP70, TYK2 | SYK 1/4885CYP2C9 3511/4885JAK3 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.