Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NQO1 | P15559 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12374841 | 0.83 | NQO1 (0.45) | CYSLTR2CYSLTR1L3MBTL1NQO1ABCB1 | |
| SCHEMBL13403306 | 0.82 | NQO1 (0.52) | CYSLTR2CYSLTR1NQO1ABCB1ABCG2 | |
| SCHEMBL14514848 | 0.81 | MAPT (0.45) | NQO1ABCB1ALDH1A1MAPTLMNA | |
| SCHEMBL2280088 | 0.81 | PADI4 (0.48) | CYSLTR2CYSLTR1L3MBTL1NQO1ABCG2 | |
| SCHEMBL2277998 | 0.81 | NQO1 (0.44) | CYSLTR2CYSLTR1L3MBTL1NQO1ABCB1 | |
| SCHEMBL2277990 | 0.81 | NQO1 (0.44) | CYSLTR2CYSLTR1L3MBTL1NQO1ABCB1 | |
| SCHEMBL2280086 | 0.81 | PADI4 (0.48) | CYSLTR2CYSLTR1L3MBTL1NQO1ABCG2 | |
| SCHEMBL2276772 | 0.80 | ABCG2 (0.47) | CYSLTR2CYSLTR1L3MBTL1NQO1ABCG2 | |
| SCHEMBL2276769 | 0.80 | ABCG2 (0.47) | CYSLTR2CYSLTR1L3MBTL1NQO1ABCG2 | |
| SCHEMBL4510106 | 0.79 | CYSLTR2 (0.44) | CYSLTR2CYSLTR1L3MBTL1NQO1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989478-B2 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-08-02 | — | — | US | disclosed |
| US-7989478-B2 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-08-02 | — | — | US | disclosed |