Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 16/20 | 0.85 |
| ▸ | AKT2 | P31751 | 12/20 | 0.85 |
| ▸ | AKT3 | Q9Y243 | 7/20 | 0.85 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.69 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.67 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | RUVBL1 | Q9Y265 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5348455 | 0.92 | AKT1 (1.00) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL12375867 | 0.90 | AKT1 (0.84) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL13711139 | 0.88 | AKT1 (0.84) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL5352476 | 0.86 | AKT1 (0.81) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL5645940 | 0.86 | AKT1 (0.87) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL29388417 | 0.86 | AKT1 (0.87) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL13711142 | 0.86 | AKT1 (0.80) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL1434365 | 0.85 | AKT1 (0.86) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL5366690 | 0.84 | AKT1 (0.84) | AKT1AKT2AKT3OPRM1OPRK1 | |
| SCHEMBL5351640 | 0.84 | AKT1 (1.00) | AKT1AKT2AKT3TDP1RUVBL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1898903-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2013-03-27 | — | — | EP | disclosed |
| US-8008317-B2 | Inhibitors of akt activtiy | MERCK SHARP & DOHME CORP. (US) | 2011-08-30 | — | — | US | disclosed |
| US-8008317-B2 | Inhibitors of akt activtiy | MERCK SHARP & DOHME CORP. (US) | 2011-08-30 | — | — | US | disclosed |
| US-20100222321-A1 | Inhibitors of akt activtiy | MERCK SHARP & DOHME LLC | 2010-09-02 | — | — | US | disclosed |
| US-20100222321-A1 | Inhibitors of akt activtiy | MERCK SHARP & DOHME LLC | 2010-09-02 | — | — | US | disclosed |
| US-7589068-B2 | Inhibitors of Akt activity | MERCK & CO., INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7589068-B2 | Inhibitors of Akt activity | MERCK & CO., INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-20080009507-A1 | Inhibitors of Akt Activity | MERCK SHARP & DOHME CORP. | 2008-01-10 | — | — | US | disclosed |
| US-20080009507-A1 | Inhibitors of Akt Activity | MERCK SHARP & DOHME CORP. | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222321-A1 | Inhibitors of akt activtiy | PIK3CA, PIK3CD, INPP5D | AKT1 8/4885AKT2 4/4885AKT3 5/4885 |
| US-20080009507-A1 | Inhibitors of Akt Activity | PIK3CD, PIK3CA, PIK3CG | AKT1 9/4885AKT2 5/4885AKT3 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.