Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.74 |
| ▸ | CTSD | P07339 | 10/20 | 0.74 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL2284759 | 0.95 | BACE1 (0.68) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL7869012 | 0.94 | BACE1 (0.73) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL7870368 | 0.89 | BACE1 (0.79) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2278853 | 0.88 | BACE1 (0.78) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2278847 | 0.88 | BACE1 (0.78) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL7870685 | 0.88 | BACE1 (0.57) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2280079 | 0.88 | BACE1 (0.77) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2280075 | 0.88 | BACE1 (0.77) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2287723 | 0.85 | BACE1 (1.00) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2279151 | 0.85 | BACE1 (1.00) | BACE1CTSDBACE2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-B1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-11-14 | — | — | EP | disclosed |
| US-7989449-B2 | 4,5-dihydro-oxazol-2-yl amine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-08-02 | — | — | US | disclosed |
| US-7989449-B2 | 4,5-dihydro-oxazol-2-yl amine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-08-02 | — | — | US | disclosed |