Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15317648 | 1.00 | MEN1 (0.60) | MEN1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL15317689 | 0.91 | MEN1 (0.66) | MEN1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL15317685 | 0.91 | MEN1 (0.66) | MEN1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL15317656 | 0.91 | MEN1 (0.66) | MEN1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL15317667 | 0.91 | MEN1 (0.69) | MEN1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL15317704 | 0.87 | MEN1 (0.63) | MEN1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL15470654 | 0.85 | MEN1 (0.60) | MEN1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL21977131 | 0.84 | MEN1 (0.59) | MEN1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4617137 | 0.84 | MEN1 (0.59) | MEN1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL12203376 | 0.83 | HSP90AA1 (0.52) | MEN1KMT2AHPGDHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003662-B2 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ERBB2, LCK, SRC | MEN1 3149/4885KMT2A 4415/4885ALDH1A1 1635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.