Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.41 |
| ▸ | CDK1 | P06493 | 4/20 | 0.41 |
| ▸ | CDK4 | P11802 | 4/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.41 |
| ▸ | CCND1 | P24385 | 4/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12384837 | 0.99 | CDK2 (0.42) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL12384828 | 0.88 | CDK2 (0.39) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL12384833 | 0.87 | CDK2 (0.38) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL12384826 | 0.86 | CDK2 (0.36) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL2656567 | 0.83 | CDK2 (0.42) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL2656562 | 0.83 | CDK2 (0.42) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL998957 | 0.82 | CDK2 (0.41) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL998015 | 0.82 | CDK2 (0.41) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL1002552 | 0.82 | CDK2 (0.41) | CDK2CCNE2CCNE1CCNB2CDK1 | |
| SCHEMBL2656028 | 0.82 | CDK2 (0.41) | CDK2CCNE2CCNE1CCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999114-B2 | Dicycloalkylcarbamoyl ureas as glucokinase activators | NOVO NORDISK A/S (DK) | 2011-08-16 | — | — | US | disclosed |
| US-7999114-B2 | Dicycloalkylcarbamoyl ureas as glucokinase activators | NOVO NORDISK A/S (DK) | 2011-08-16 | — | — | US | disclosed |
| US-20080319028-A1 | Dicycloalkylcarbamoyl Ureas As Glucokinase Activators | NOVO NORDISK A/S (DK) | 2008-12-25 | — | — | US | disclosed |
| US-20080319028-A1 | Dicycloalkylcarbamoyl Ureas As Glucokinase Activators | NOVO NORDISK A/S (DK) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319028-A1 | Dicycloalkylcarbamoyl Ureas As Glucokinase Activators | GCK, HK1, GCKR | CDK2 547/4885CCNE2 2893/4885CCNE1 2708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.