Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.43 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.43 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.43 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.43 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1064768 | 0.84 | MAPT (0.78) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2300679 | 0.84 | MAPT (0.78) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL22209242 | 0.84 | MAPT (0.78) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2856265 | 0.84 | MAPT (0.78) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL595690 | 0.84 | MAPT (1.00) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24303272 | 0.83 | MAPT (0.76) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2852811 | 0.83 | MAPT (0.76) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2064195 | 0.83 | MAPT (0.76) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2300568 | 0.83 | MAPT (0.76) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL21604946 | 0.81 | MAPT (0.78) | MAPTPOLBSMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399451-B2 | Heterocyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-03-19 | — | — | US | disclosed |
| US-20110190255-A1 | HETEROCYCLIC COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190255-A1 | HETEROCYCLIC COMPOUNDS | S1PR1, S1PR3, S1PR5 | MAPT 4760/4885POLB 3979/4885SMN1; SMN2 1771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.