Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 15/20 | 0.59 |
| ▸ | KCNJ5 | P48544 | 6/20 | 0.44 |
| ▸ | KCNJ3 | P48549 | 6/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15809184 | 0.99 | KCNA5 (0.58) | KCNA5KCNJ5KCNJ3CHRM2CHRM1 | |
| SCHEMBL1236846 | 0.97 | KCNA5 (0.64) | KCNA5KCNJ5KCNJ3CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL15809246 | 0.96 | KCNA5 (0.63) | KCNA5KCNJ5KCNJ3CHRM2CHRM1 | |
| SCHEMBL1239285 | 0.96 | KCNA5 (0.64) | KCNA5KCNJ5KCNJ3CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL15809339 | 0.96 | KCNA5 (0.63) | KCNA5KCNJ5KCNJ3CHRM2CHRM1 | |
| SCHEMBL1239034 | 0.94 | KCNA5 (0.66) | KCNA5KCNJ5KCNJ3 | |
| Hydrochloric Acid SCHEMBL15809259 | 0.94 | KCNA5 (0.65) | KCNA5KCNJ5KCNJ3 | |
| SCHEMBL1238517 | 0.93 | KCNA5 (0.69) | KCNA5KCNJ5KCNJ3CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL15809221 | 0.93 | KCNA5 (0.68) | KCNA5KCNJ5KCNJ3CHRM2CHRM1 | |
| SCHEMBL1238816 | 0.90 | KCNA5 (0.62) | KCNA5KCNJ5KCNJ3CYP2D6HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2467364-A2 | NITROGEN-CONTAINING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF ATRIAL FIBRILLATION | Otsuka Pharmaceutical Co., Ltd. (JP) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011021726-A2 | NITROGEN-CONTAINING COMPOUND AND PHARMACEUTICAL COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2011-02-24 | — | — | WO | disclosed |