Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 3/20 | 0.70 |
| ▸ | EHMT2 | Q96KQ7 | 11/20 | 0.63 |
| ▸ | KDM1A | O60341 | 1/20 | 0.63 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.63 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.53 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | WHR1 | P49842 | 1/20 | 0.47 |
| ▸ | EHMT1 | Q9H9B1 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29613418 | 0.95 | NSD2 (0.76) | NSD2EHMT2KDM1ARCOR1DNMT3A | |
| SCHEMBL1748471 | 0.95 | NSD2 (0.76) | NSD2EHMT2KDM1ARCOR1DNMT3A | |
| SCHEMBL2334216 | 0.87 | EHMT2 (0.68) | NSD2EHMT2KDM1ARCOR1DNMT3A | |
| SCHEMBL2331523 | 0.83 | BTK (0.52) | NSD2DNMT3APIK3CDALDH1A1 | |
| SCHEMBL2331519 | 0.83 | BTK (0.52) | NSD2DNMT3APIK3CDALDH1A1 | |
| SCHEMBL1428017 | 0.83 | EHMT2 (0.74) | NSD2EHMT2KDM1ARCOR1DNMT3A | |
| SCHEMBL15280234 | 0.83 | EHMT2 (0.74) | NSD2EHMT2KDM1ARCOR1DNMT3A | |
| SCHEMBL20621265 | 0.82 | KMT5A (0.62) | NSD2EHMT2KMT5AWHR1EHMT1 | |
| SCHEMBL29453059 | 0.82 | KMT5A (0.62) | NSD2EHMT2KMT5AWHR1EHMT1 | |
| SCHEMBL27223024 | 0.81 | NSD2 (0.70) | NSD2EHMT2KDM1ARCOR1DNMT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324226-B2 | Therapeutic oxy-phenyl-aryl compounds and their use | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2012-12-04 | — | — | US | disclosed |
| US-20110201592-A1 | Therapeutic Oxy-Phenyl-Aryl Compounds and Their Use | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2011-08-18 | — | — | US | disclosed |
| WO-2009053694-A1 | THERAPEUTIC OXY-PHENYL-ARYL COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201592-A1 | Therapeutic Oxy-Phenyl-Aryl Compounds and Their Use | CHEK2, CHEK1, PLK1 | NSD2 2599/4885EHMT2 1320/4885KDM1A 1185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.