Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 15/20 | 0.59 |
| ▸ | BCR | P11274 | 15/20 | 0.59 |
| ▸ | BRAF | P15056 | 4/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.52 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12397175 | 0.90 | BRAF (0.57) | ABL1BCRBRAFKITDDR1 | |
| SCHEMBL12397542 | 0.88 | ABL1 (0.56) | ABL1BCRBRAFKITDDR1 | |
| SCHEMBL12397466 | 0.87 | ABL1 (0.51) | ABL1BCRBRAFKITDDR1 | |
| SCHEMBL12397581 | 0.86 | ABL1 (0.69) | ABL1BCR | |
| SCHEMBL12397493 | 0.86 | ABL1 (0.52) | ABL1BCRBRAFKITDDR1 | |
| SCHEMBL12397249 | 0.85 | BRAF (0.56) | ABL1BCRBRAF | |
| SCHEMBL12396960 | 0.84 | ABL1 (0.52) | ABL1BCRBRAFKITDDR1 | |
| SCHEMBL12396980 | 0.84 | DDR2 (0.52) | ABL1BCRBRAFKITDDR1 | |
| SCHEMBL12397120 | 0.83 | ABL1 (0.52) | ABL1BCRBRAFKITDDR1 | |
| SCHEMBL12397644 | 0.83 | BRAF (0.69) | ABL1BCRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889665-B2 | Chemical compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| US-8889665-B2 | Chemical compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| US-20110183952-A1 | NEW CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-07-28 | — | — | US | disclosed |
| US-20110183952-A1 | NEW CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183952-A1 | NEW CHEMICAL COMPOUNDS | MKI67, CCNA1, CCNT1 | ABL1 136/4885BCR 922/4885BRAF 525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.