Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 7/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.37 |
| ▸ | ITGAV | P06756 | 2/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12081279 | 0.85 | KCNA5 (0.59) | KCNA5NAMPTITGB3ITGAVITGB5 | |
| Hydrochloric Acid SCHEMBL15986287 | 0.84 | KCNA5 (0.59) | KCNA5NAMPT | |
| Hydrochloric Acid SCHEMBL12080707 | 0.82 | KCNA5 (0.56) | KCNA5NAMPTADRB3ADRB1ITGB3 | |
| SCHEMBL12081591 | 0.80 | KCNA5 (0.56) | KCNA5NAMPT | |
| SCHEMBL1238479 | 0.80 | KCNA5 (0.66) | KCNA5NAMPT | |
| Hydrochloric Acid SCHEMBL15986337 | 0.80 | KCNA5 (0.56) | KCNA5NAMPT | |
| Hydrochloric Acid SCHEMBL12080913 | 0.80 | KCNA5 (0.58) | KCNA5NAMPTITGB3ITGAVITGB5 | |
| SCHEMBL15986302 | 0.79 | KCNA5 (0.67) | KCNA5NAMPT | |
| SCHEMBL1239837 | 0.79 | KCNA5 (0.65) | KCNA5NAMPTGRIN1GRIN2B | |
| SCHEMBL1237165 | 0.78 | KCNA5 (0.66) | KCNA5NAMPTGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2467364-A2 | NITROGEN-CONTAINING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF ATRIAL FIBRILLATION | Otsuka Pharmaceutical Co., Ltd. (JP) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011021726-A2 | NITROGEN-CONTAINING COMPOUND AND PHARMACEUTICAL COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2011-02-24 | — | — | WO | disclosed |