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SCHEMBL1241460

SCHEMBL1241460

CCOc1ccc(CCN(C(=O)Nc2ncc(SCC(C)(C)C(=O)O)s2)C2CCC(C)CC2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PPARG P37231 1/20 0.39
▸ PPARD Q03181 1/20 0.39
▸ PPARA Q07869 1/20 0.39
▸ CDK2 P24941 13/20 0.38
▸ CCNE2 O96020 7/20 0.38
▸ CCNE1 P24864 7/20 0.38
▸ HDAC3 O15379 2/20 0.35
▸ HDAC4 P56524 2/20 0.35
▸ HDAC1 Q13547 2/20 0.35
▸ HDAC7 Q8WUI4 2/20 0.35
▸ HDAC2 Q92769 2/20 0.35
▸ HDAC10 Q969S8 2/20 0.35
▸ HDAC11 Q96DB2 2/20 0.35
▸ HDAC8 Q9BY41 2/20 0.35
▸ HDAC6 Q9UBN7 2/20 0.35
▸ HDAC9 Q9UKV0 2/20 0.35
▸ HDAC5 Q9UQL6 2/20 0.35
▸ CDK1 P06493 5/20 0.34
▸ CCNB1 P14635 5/20 0.34
▸ CCNB2 O95067 4/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12751228 1.00 PPARG (0.39) PPARGPPARDPPARACDK2CCNE2
SCHEMBL12204230 0.93 PPARA (0.46) PPARGPPARDPPARACDK2CCNE2
SCHEMBL2657573 0.93 PPARA (0.40) PPARGPPARDPPARACDK2CCNE2
SCHEMBL1241347 0.93 PPARA (0.40) PPARGPPARDPPARACDK2CCNE2
SCHEMBL1241543 0.90 CDK2 (0.48) PPARGPPARDPPARACDK2CCNE2
SCHEMBL2658053 0.90 CDK2 (0.48) PPARGPPARDPPARACDK2CCNE2
SCHEMBL1238619 0.89 CCNE1 (0.40) PPARGPPARDPPARACDK2CCNE2
SCHEMBL12204778 0.86 PPARA (0.47) PPARGPPARDPPARACDK2CCNE2
SCHEMBL1240846 0.86 CCNE2 (0.37) PPARACDK2CCNE2CCNE1HDAC3
SCHEMBL2658423 0.86 CCNE2 (0.37) PPARACDK2CCNE2CCNE1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8586614-B2 Urea glucokinase activators NOVO NORDISK A/S (DK) 2013-11-19 — — US disclosed
EP-2377856-A1 Urea glucokinase activators NOVO NORDISK A/S (DK) 2011-10-19 — — EP disclosed
US-20110077234-A1 Urea Glucokinase Activators NOVO NORDISK A/S (DK) 2011-03-31 — — US disclosed
US-7884210-B2 {2-[3-(2-Cyclohex-1-enyl-ethyl)-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid; for treatment of type 2 diabetes NOVO NORDISK A/S (DK) 2011-02-08 — — US disclosed
US-20090105482-A1 Urea Glucokinase Activators NOVO NORDISK A/S (DK) 2009-04-23 — — US disclosed
EP-1904467-A1 UREA GLUCOKINASE ACTIVATORS Novo Nordisk A/S (DK) 2008-04-02 — — EP disclosed
WO-2007006814-A1 UREA GLUCOKINASE ACTIVATORS NOVO NORDISK A/S (DK) 2007-01-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090105482-A1 Urea Glucokinase Activators GCK, GCKR, HK2 PPARG 844/4885PPARD 1805/4885PPARA 2109/4885
US-20110077234-A1 Urea Glucokinase Activators GCK, GCKR, HK2 PPARG 844/4885PPARD 1805/4885PPARA 2109/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.