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SCHEMBL12414859

SCHEMBL12414859

CCCCCN1/C(=C/C=C2\CCC(/C=C/C3=[N+](CCCCC)c4ccc(Br)cc4C3(C)C)=C2Sc2nnnn2-c2ccccc2)C(C)(C)c2cc(Br)ccc21

nearest known ligand 0.49

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ PRMT1 Q99873 7/20 0.49
▸ PRMT5 O14744 2/20 0.48
▸ PRMT8 Q9NR22 2/20 0.48
▸ CARM1 Q86X55 1/20 0.48
▸ FOLR1 P15328 5/20 0.39
▸ HTR1A P08908 1/20 0.38
▸ PTPN1 P18031 1/20 0.38
▸ FOLH1 Q04609 3/20 0.35
▸ EGFR P00533 2/20 0.31
▸ TLR2 O60603 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12414924 0.95 PTPN1 (0.46) PRMT1PRMT5PRMT8CARM1FOLR1
SCHEMBL12415035 0.93 PRMT1 (0.49) PRMT1PRMT5PRMT8CARM1FOLR1
SCHEMBL12414856 0.93 PRMT1 (0.41) PRMT1PRMT5PRMT8CARM1FOLR1
SCHEMBL12414923 0.92 FOLR1 (0.47) PRMT1PRMT5PRMT8CARM1FOLR1
SCHEMBL12415019 0.90 PRMT1 (0.46) PRMT1PRMT5PRMT8CARM1FOLR1
SCHEMBL12414930 0.90 FOLR1 (0.41) PRMT1PRMT5PRMT8CARM1FOLR1
SCHEMBL12414927 0.88 PTPN1 (0.46) PRMT1PRMT5PRMT8CARM1FOLR1
SCHEMBL12414862 0.88 PRMT1 (0.46) PRMT1PRMT5PRMT8CARM1FOLR1
SCHEMBL12414931 0.85 FOLR1 (0.47) PRMT1PRMT5PRMT8CARM1FOLR1
SCHEMBL18256965 0.85 FOLR1 (0.42) PRMT1PRMT5PRMT8CARM1FOLR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110165518-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AGFA GRAPHICS NV (BE) 2011-07-07 — — US disclosed