Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2195005 | 0.87 | GRM5 (1.00) | GRM5CYP1A2CYP2C9CYP3A4 | |
| SCHEMBL15354538 | 0.87 | GRM5 (0.68) | GRM5CYP1A2 | |
| SCHEMBL12416378 | 0.84 | GRM5 (0.61) | GRM5CYP1A2 | |
| SCHEMBL15354537 | 0.84 | GRM5 (0.67) | GRM5CYP1A2 | |
| SCHEMBL12412459 | 0.83 | CYP1A2 (0.64) | GRM5CYP1A2CYP2C9CYP3A4 | |
| SCHEMBL12416368 | 0.81 | GRM5 (0.76) | GRM5 | |
| SCHEMBL6927550 | 0.81 | GRM5 (0.79) | GRM5CYP1A2CYP2C9CYP3A4 | |
| SCHEMBL6928845 | 0.81 | GRM5 (0.75) | GRM5CYP1A2 | |
| SCHEMBL12416415 | 0.81 | CYP1A2 (0.64) | GRM5CYP1A2CYP2C9CYP3A4 | |
| SCHEMBL6929686 | 0.81 | GRM5 (0.75) | GRM5CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569308-B2 | Substituted heteroarylamine carboxamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same | VANDERBILT UNIVERSITY (US) | 2013-10-29 | — | — | US | disclosed |
| US-20110172247-A1 | SUBSTITUTED HETEROARYLAMINE CARBOXAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | VANDERBILT UNIVERSITY | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172247-A1 | SUBSTITUTED HETEROARYLAMINE CARBOXAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | GRM5, GRIK5, GRM2 | GRM5 1/4885CYP1A2 3795/4885CYP2C9 3237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.