Sugi Predict

Sugi Predict / Compounds / SCHEMBL1241639

SCHEMBL1241639

SCHEMBL1241639

Cc1c(-c2ccc(OC(F)(F)F)cc2)cccc1N(Cc1ccc(C(C)(C)C)cc1)C(=O)C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ SERPINE1 P05121 10/20 0.54
▸ NR1H4 Q96RI1 2/20 0.43
▸ EPHX2 P34913 1/20 0.43
▸ GCGR P47871 2/20 0.43
▸ GIPR P48546 2/20 0.43
▸ GLP1R P43220 1/20 0.43
▸ PPARG P37231 2/20 0.43
▸ PPARD Q03181 2/20 0.43
▸ PPARA Q07869 2/20 0.43
▸ FFAR1 O14842 1/20 0.39
▸ FFAR4 Q5NUL3 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ MAPK1 P28482 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ PTGES O14684 1/20 0.39
▸ ALOX5 P09917 1/20 0.39
▸ TRPV1 Q8NER1 1/20 0.39
▸ CYP2C9 P11712 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1242204 0.91 SERPINE1 (0.60) SERPINE1NR1H4EPHX2GCGRGIPR
SCHEMBL1242370 0.91 NR1H4 (0.44) SERPINE1NR1H4EPHX2GCGRGIPR
SCHEMBL1241739 0.87 SERPINE1 (0.51) SERPINE1NR1H4EPHX2GCGRGIPR
SCHEMBL1241545 0.83 SERPINE1 (0.57) SERPINE1NR1H4EPHX2GCGRGIPR
SCHEMBL1242230 0.83 SERPINE1 (0.57) SERPINE1NR1H4EPHX2GCGRGIPR
SCHEMBL1239503 0.82 SERPINE1 (0.56) SERPINE1NR1H4EPHX2GCGRGIPR
SCHEMBL1241530 0.82 SERPINE1 (0.56) SERPINE1NR1H4EPHX2GCGRGIPR
SCHEMBL1241743 0.82 SERPINE1 (0.49) SERPINE1NR1H4EPHX2GCGRGIPR
SCHEMBL1239952 0.82 SERPINE1 (0.51) SERPINE1NR1H4EPHX2GCGRGIPR
SCHEMBL1241505 0.82 SERPINE1 (0.47) SERPINE1NR1H4EPHX2GCGRGIPR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7884234-B2 N-[4-(tert-butyl)benzyl]-N-[4 -(trifluoromethoxy)biphenyl-3-yl]oxamic Acid; Inhibitors of plasminogen activator inhibitor-1 (PAI-1); thrombogenesis, fibrogenesis, accumulation of visceral fat, cell proliferation, angiogenesis INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) 2011-02-08 — — US disclosed
US-20090215899-A9 N-Phenyloxamide derivatives INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) 2009-08-27 — — US disclosed
EP-2072498-A1 N-PHENYLOXAMIDIC ACID DERIVATIVE Institute of Medicinal Molecular Design, Inc. (JP) 2009-06-24 — — EP disclosed
US-20080249175-A1 N-Phenyloxamide derivatives INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) 2008-10-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080249175-A1 N-Phenyloxamide derivatives SERPINE1, SERPINH1, F12 SERPINE1 1/4885NR1H4 4184/4885EPHX2 958/4885
US-20090215899-A9 N-Phenyloxamide derivatives SERPINE1, SERPINH1, F12 SERPINE1 1/4885NR1H4 4184/4885EPHX2 958/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.