Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.51 |
| ▸ | JAK3 | P52333 | 4/20 | 0.51 |
| ▸ | ABL1 | P00519 | 3/20 | 0.45 |
| ▸ | BCR | P11274 | 3/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.42 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13154294 | 0.91 | JAK2 (0.54) | JAK2JAK3ABL1BCRSYK | |
| SCHEMBL12423655 | 0.91 | JAK2 (0.62) | JAK2JAK3ABL1BCRSYK | |
| SCHEMBL12423135 | 0.89 | JAK2 (0.58) | JAK2JAK3ABL1BCRSYK | |
| SCHEMBL12423657 | 0.88 | JAK2 (0.51) | JAK2JAK3ABL1BCRSYK | |
| SCHEMBL12423654 | 0.87 | JAK2 (0.52) | JAK2JAK3ABL1BCRSYK | |
| SCHEMBL12423636 | 0.87 | JAK2 (0.62) | JAK2JAK3ABL1BCRSYK | |
| SCHEMBL12423649 | 0.87 | JAK2 (0.50) | JAK2JAK3ABL1BCRPLK4 | |
| SCHEMBL12423160 | 0.87 | JAK2 (0.61) | JAK2JAK3ABL1BCRSYK | |
| SCHEMBL14100240 | 0.86 | JAK2 (0.51) | JAK2JAK3ABL1BCRSYK | |
| SCHEMBL13154290 | 0.85 | JAK2 (0.53) | JAK2JAK3ABL1BCRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977481-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-7977481-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-7803806-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-7803806-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2010-09-28 | — | — | US | disclosed |