Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | JAK3 | P52333 | 4/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12423677 | 0.94 | JAK2 (0.45) | JAK2JAK3AKT3BCHEACHE | |
| SCHEMBL12423683 | 0.91 | JAK2 (0.54) | JAK2JAK3AKT3ABL1PDGFRB | |
| SCHEMBL12423669 | 0.89 | JAK2 (0.53) | JAK2JAK3AKT3ABL1PDGFRB | |
| SCHEMBL13154242 | 0.88 | JAK2 (0.46) | JAK2JAK3AKT3ABL1PDGFRB | |
| SCHEMBL12423671 | 0.86 | JAK2 (0.45) | JAK2JAK3AKT3ABL1PDGFRB | |
| SCHEMBL12423766 | 0.84 | JAK2 (0.56) | JAK2JAK3AKT3ABL1PDGFRB | |
| SCHEMBL13154245 | 0.81 | JAK2 (0.53) | JAK2JAK3AKT3ABL1PDGFRB | |
| SCHEMBL13154295 | 0.81 | JAK2 (0.51) | JAK2JAK3ABL1PDGFRBBCR | |
| SCHEMBL12423747 | 0.80 | JAK2 (0.46) | JAK2JAK3AKT3ABL1PDGFRB | |
| SCHEMBL13154243 | 0.79 | JAK2 (0.57) | JAK2JAK3AKT3ABL1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977481-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2011-07-12 | — | — | US | disclosed |