Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | NQO2 | P16083 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SMC2 | O95347 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.47 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.47 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12423800 | 0.93 | MAP2K1 (0.67) | MAP2K1CYP2C9CYP2C19CYP3A4MAP2K2 | |
| SCHEMBL2293700 | 0.89 | MAP2K1 (0.80) | MAP2K1CYP2C9CYP2C19CYP3A4MAP2K2 | |
| SCHEMBL12423789 | 0.83 | MAP2K1 (0.61) | MAP2K1CYP2C9CYP2C19CYP3A4MAP2K2 | |
| SCHEMBL12423794 | 0.83 | MAP2K1 (0.61) | MAP2K1CYP2C9CYP2C19CYP3A4MAP2K2 | |
| SCHEMBL12423795 | 0.82 | MAP2K1 (0.74) | MAP2K1CYP2C9CYP2C19CYP3A4MAP2K2 | |
| SCHEMBL12423783 | 0.80 | MAP2K1 (0.77) | MAP2K1CYP2C9CYP2C19CYP3A4MAP2K2 | |
| SCHEMBL4752120 | 0.79 | MAP2K1 (1.00) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL15130135 | 0.79 | MAP2K1 (0.67) | MAP2K1CYP2C9CYP2C19CYP3A4MAP2K2 | |
| SCHEMBL1579947 | 0.79 | MAP2K1 (1.00) | MAP2K1CYP2C9CYP2C19CYP3A4MAP2K2 | |
| SCHEMBL1578632 | 0.78 | MAP2K1 (0.64) | MAP2K1CYP2C9CYP2C19CYP3A4MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841462-B2 | Bicyclic heterocycles as MEK kinase inhibitors | GENENTECH, INC. | 2014-09-23 | — | — | US | disclosed |
| US-20110190257-A1 | BICYCLIC HETEROCYCLES AS MEK KINASE INHIBITORS | GENETECH, INC. (US) | 2011-08-04 | — | — | US | disclosed |
| WO-2010003025-A1 | BICYCLIC HETEROCYCLES AS MEK KINASE INHIBITORS | GENENTECH, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190257-A1 | BICYCLIC HETEROCYCLES AS MEK KINASE INHIBITORS | MAP2K7, MAP3K1, MAP3K5 | MAP2K1 11/4885CYP2C9 2474/4885CYP2C19 1711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.