Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | AXL | P30530 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812811 | 0.98 | KMT2A (0.65) | KMT2AAXLMEN1PDE4AKDM4E | |
| SCHEMBL17179514 | 0.84 | KMT2A (0.49) | KMT2AAXLADORA3ADORA1ADORA2A | |
| SCHEMBL16438333 | 0.84 | KMT2A (0.49) | KMT2AAXLADORA3ADORA1ADORA2A | |
| SCHEMBL13768978 | 0.84 | MAPK1 (0.50) | KMT2AAXLADORA3 | |
| SCHEMBL1937546 | 0.83 | KMT2A (0.71) | KMT2AAXLMEN1PDE4AKDM4E | |
| SCHEMBL1934159 | 0.81 | KMT2A (0.69) | KMT2AAXLMEN1PDE4AKDM4E | |
| SCHEMBL24799800 | 0.81 | KMT2A (0.68) | KMT2AAXLMEN1PDE4AKDM4E | |
| SCHEMBL2302601 | 0.81 | KMT2A (0.68) | KMT2AAXLMEN1PDE4AKDM4E | |
| SCHEMBL19244047 | 0.81 | KMT2A (0.68) | KMT2AAXLMEN1PDE4AKDM4E | |
| SCHEMBL21593571 | 0.81 | KMT2A (0.68) | KMT2AAXLMEN1PDE4APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101409-A1 | PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 | NOVARTIS AG (CH) | 2011-08-25 | — | — | WO | disclosed |