SCHEMBL12425318

SCHEMBL12425318

CCCSCc1ccc(C2CCC(C)(C)CC2)cc1

nearest known ligand 0.38

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 2/20 0.38
SPHK1 Q9NYA1 12/20 0.36
ACE P12821 1/20 0.35
APP P05067 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
DRD2 P14416 1/20 0.33
PPARG P37231 1/20 0.32
PPARA Q07869 1/20 0.32
SPHK2 Q9NRA0 7/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12432133 0.74 IDO1 (0.41) CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL8995561 0.74 ESR2 (0.44) ESR2SPHK1APPCYP3A4CYP2D6
SCHEMBL9648146 0.70 ESR2 (0.41) ESR2SPHK1DRD2SPHK2
SCHEMBL9758150 0.70 ESR2 (0.41) ESR2SPHK1DRD2SPHK2
SCHEMBL25636409 0.68 RECQL (0.38) CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL9715891 0.68 SPHK1 (0.44) ESR2SPHK1SPHK2
SCHEMBL9757949 0.68 SPHK1 (0.44) ESR2SPHK1SPHK2
SCHEMBL25039518 0.68 ESR2 (0.48) ESR2APPCYP3A4CYP2D6CYP2C9
SCHEMBL16152681 0.68 ESR2 (0.48) ESR2APPCYP3A4CYP2D6CYP2C9
SCHEMBL3148250 0.68 ESR2 (0.75) ESR2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1423685-B1 ARRAY OF PIEZOELECTRIC RESONATORS FOR THE DETECTION OF TRACE AMOUNTS OF A SUBSTANCE M S TECH LTD (IL) 2011-08-24 EP disclosed